INCORPORATION OF TRITIATED THYMIDINE INTO DNA AFTER ORAL ADMINISTRATION
Journal Article
·
· Proc. Soc. Exptl. Biol. Med.
Parenteral tritiated thymidine (H/sup 3/TDR) was administered via a stomach tube to rats, mice, and guinea pigs. Some ingested H/sup 3/TDR was absorbed and labeled proliferating cells of gastrointestinal mucosa as early as 2 hr after ingestion in guinea pigs. Labeling of diverse tissues, including proliferative cells of the testes was seen in rats and mice 7 1/2 hr after ingestion. Some of the H/sup 3/TDR was degraded to tritiated water and small amounts of nonvolatile H/sup 3/ activity were excreted in the urine. The significance of absorption of H/sup 3/TDR through intestinal mucosa is discussed as related to potential hazard. (auth)
- Research Organization:
- Veterans Administration Hospital, Dallas; Univ. of Texas, Dallas; and Brookhaven National Lab., Upton, N.Y.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-008497
- OSTI ID:
- 4104555
- Report Number(s):
- BNL-5005
- Journal Information:
- Proc. Soc. Exptl. Biol. Med., Journal Name: Proc. Soc. Exptl. Biol. Med. Vol. Vol: 106
- Country of Publication:
- United States
- Language:
- English
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