THE NATURE OF THE RADIOSENSITIVE CELLS IN THE DEVELOPING NERVOUS SYSTEM STUDIED WITH TRITIATED THYMIDINE
Technical Report
·
OSTI ID:4841048
Presented at the Symposium on the Effects of Ionizing Radiation on the Nervous System, International Atomic Energy Agency, Vienna, June 5-- 9, 1961. Radiosensitive cells in the developing nervous systems of rats were studied. Experiments using radiation were combined with experiments in which tritiated thymidine (H/sub 3/T) was given to the animals. Cells that were replicating their chromosomes in preparation for mitotic division took up H/sub 3/T and became radioactively labeled. If an early embryo was irradiated with 200 r one hour after H/sub 3/T was given and then killed for study 4 hr later, the labeled cells had moved into the ventricular surface and a few had begun to divide. Large numbers of cells were killed, but very few were labeled. If radiation was given 4 hrs after H/sub 3/T to a similar early embryo and it was then killed 4 hr after that, large numbers of labeled cells were found dead. The relative number of dead labeled and unlabeled cells varied -with the proliferative pattern in different regions. (M.C.G.)
- Research Organization:
- New England Deaconess Hospital, Boston; and Harvard Univ., Boston. Medical School
- NSA Number:
- NSA-15-028991
- OSTI ID:
- 4841048
- Report Number(s):
- TID-13420
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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