I. INFLUENCE OF TOTAL-BODY X-RAYS ON THE KINETICS OF ERYTHROCYTE ENZYMES AS A BIOLOGICAL DOSIMETER. II. BIO-CHEMICAL STUDIES OF THE RAT BRAIN. Annual Progress Report III, June 1, 1962 to MaY 31, 1963
Technical Report
·
OSTI ID:4100759
An internal x ray dosimeter was found in a rat erythrocyte enzyme, nucleoside phosphorylase. At all total-body x ray doses tested from 100 to 1000 r, this enzyme was inhibited but the rate of inhibition was closely similar for the 250, 500, 750, and 1000 r in the postirradiation interval from 0 to 48 hr. However, the time and degree of recovery of enzyme activity postirradiation were dose dependent. Thus, complete recovery after 100 r was in 116 hr, after 250 r in 155 hr, and after 500 r in 221 hr. With a 750-r dose only partial recovery of activity was noted at 216 hr, but at 1000-r dose there was no recovery of enzyme activity. The inhibition of this enzyme after 100 r was 3l% in 48 hr; after 250 T, 59% in 72 hr; after 500 r, 73% in 96 hr; after 750 r, 75% in 96 hr; and after 1000 r, 76% in 96 hr. In the immediate postirradiation interval of 16 hr, 100-r totalbody x irradiation of the rat inhibited erythrocyte nucleoside phosphorylase 14% and after 500 r the inhibition was 36%. A microtechnique was developed and initiated for testing the erythrocyte nucleoside phosphorylase activity which will permit repeated sampling of blood from rats and other subjects. This will permit using each animal as its own preirradiation control and the same animal will also be used for multiple sampling of blood throughout the postirradiation period. (auth)
- Research Organization:
- Texas. Univ., Galveston. Medical Branch
- NSA Number:
- NSA-18-009832
- OSTI ID:
- 4100759
- Report Number(s):
- AD-403354L
- Country of Publication:
- United States
- Language:
- English
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