EFFECT OF X-IRRADIATION AND NITROGEN MUSTARD ON IRON INCORPORATION IN RAT ERYTHROCYTES

Journal Article · Sun Jan 01 04:00:00 EST 1961 · Laboratory Investigation (U.S.)

OSTI ID:4094594

Uzel, A R; Farrington, E; Warren, S

Groups of Deaconess-Slonaker rats were subjected to various doses of x irradiation and nitrogen mustard and injected with Fe/sup 59/ as a tracer. After total-body irradiation of varying doses, the per cent uptake of Fe/sup 59/ in peripheral erythrocytes was reduced, and the time was prolonged. Recovery was well along by the tenth day. Both depression and recovery were related to dose. Localized irradiation produced erythroid cell depression similar in degree and pattern to that following total-body irradiation. After administration of nitrogen mustard, changes in Fe/sup 59/ uptake similar to those found after total- body irradiation were observed in the peripheral blood. Iron not utilized by bone marrow is deposited in the liver, and, possibly, elsewhere. At present, the nature of the mechanism that governs the delay of erythrocyte appearance in peripheral blood and of that responsible for incomplete or delayed recovery remains obscure. (auth)

• Research Organization: New England Deaconess Hospital, Boston
• NSA Number: NSA-15-010729
• OSTI ID: 4094594
• Journal Information: Laboratory Investigation (U.S.), Journal Name: Laboratory Investigation (U.S.) Vol. Vol: 10; ISSN LAINA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BONE MARROW
ERYTHROCYTES
IRON 59
LIVER
METABOLISM
NITROGEN COMPOUNDS
RADIATION DOSES
RADIATION EFFECTS
RATS
RECOVERY
TRACER TECHNIQUES
X RADIATION