Response of femoral and vertebral colony-forming units to $sup 226$Ra internal contamination in mice

Journal Article · Mon Dec 01 04:00:00 EST 1975 · Radiat. Res., v. 64, no. 3, pp. 467-474

OSTI ID:4087893

Svoboda, V; Kofranek, V

In mice given intraperitoneally 0.034 $mu$Ci of $sup 226$Ra/g body weight the peripheral blood counts, marrow cellularity in femora and lumbar vertebrae, and the colony counts and $sup 59$Fe uptake in spleens of heavily irradiated hosts after grafting either femoral or vertebral myeloid cells were determined. In mice treated with 0.030 $mu$Ci of $sup 226$Ra/g the activity per 10 mg of wet bone tissue was computed and the data obtained in femoral ends and diaphyses and in lumbar vertebrae were correlated to the hematological findings. The effect of internally retained $sup 226$Ra is manifested by serious changes in femoral and vertebral hemopoiesis and in peripheral blood counts. The vertebral marrow is more seriously damaged as observed in the colony counts and $sup 59$Fe uptake in recipient spleens. This unequal response of femoral and vertebral marrow is discussed in relation to the $sup 226$Ra activity retained and the area of endosteal surfaces. (auth)

• Research Organization: Inst. of Hygiene and Epidemiology, Prague
• NSA Number: NSA-33-015103
• OSTI ID: 4087893
• Journal Information: Radiat. Res., v. 64, no. 3, pp. 467-474, Journal Name: Radiat. Res., v. 64, no. 3, pp. 467-474; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

*BLOOD FORMATION-- BIOLOGICAL RADIATION EFFECTS
*BONE MARROW-- BIOLOGICAL RADIATION EFFECTS
560162* --Biomedical Sciences
Applied Studies--Radiation Effects--Radionuclide Effects--Internal Source--Animals
CFU
COMPARATIVE EVALUATIONS
FEMUR
INTERNAL IRRADIATION
INTRAPERITONEAL INJECTION
MICE
N48620* --Life Sciences--Radionuclide Effects (Internal Source)--Animals
RADIUM 226
VERTEBRAE