Temporal and spatial response of marrow colony-forming cells (CFU-s and CFU-C) after /sup 226/Ra Incorporation in BALB/c Mice
Journal Article
·
· Radiat. Res.; (United States)
The numbers of hemopoietic cells (CFU-s and CFU-c) were assayed by colony tests at different times after injection of either 230 or 660 kBq /sup 226/Ra/kg in BALB/c mice. Assays were performed for marrow sites surrounded by trabecular bone (distal end of femur, lumbar vertebra, sternum) and for the femoral diaphysis where axial marrow and marrow near cortical bone were examined separately. The response in number of CFU-s and CFU-c from various marrow sites varied remarkably. Radiation-induced hemopoietic changes were not strictly related to the surrounding trabecular or cortical bone structure. The number and concentration of CFU-s and CFU-c were most altered in marrow sites which contained a high proportion of CFU-s in DNA synthesis. Fewer alterations in the number of hemopoietic cells were noticed after injection of 230 kBq /sup 226/Ra/kg than after 660 kBq /sup 226/Ra/kg. After 230 kBq /sup 226/Ra/kg bone marrow cellularity and the number of CFU-s and CFU-c frequently increased above the control level, while after 660 kBq /sup 226/Ra/kg only depressions below the control level occurred.
- Research Organization:
- Belgian Nuclear Centre, Mol
- OSTI ID:
- 5807150
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 88:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560122* -- Radiation Effects on Cells-- Internal Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD FORMATION
BONE MARROW CELLS
BONE SEEKERS
CFU
CONNECTIVE TISSUE CELLS
EVEN-EVEN NUCLEI
HAZARDS
HEALTH HAZARDS
HEAVY NUCLEI
INJECTION
INTAKE
ISOTOPES
MAMMALS
MICE
NUCLEI
RADIATION EFFECTS
RADIATION HAZARDS
RADIOISOTOPES
RADIONUCLIDE ADMINISTRATION
RADIUM 226
RADIUM ISOTOPES
RODENTS
SOMATIC CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD FORMATION
BONE MARROW CELLS
BONE SEEKERS
CFU
CONNECTIVE TISSUE CELLS
EVEN-EVEN NUCLEI
HAZARDS
HEALTH HAZARDS
HEAVY NUCLEI
INJECTION
INTAKE
ISOTOPES
MAMMALS
MICE
NUCLEI
RADIATION EFFECTS
RADIATION HAZARDS
RADIOISOTOPES
RADIONUCLIDE ADMINISTRATION
RADIUM 226
RADIUM ISOTOPES
RODENTS
SOMATIC CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES