CHANGES IN THE DURATION OF THE CENTRAL INHIBITORY EFFECT OF BARBITAL AND AMOBARBITAL IN IRRADIATED RATS

Journal Article · Tue Jan 01 04:00:00 EST 1963 · Sb. Ved. Praci Lekar. Fak. Karlovy Univ. Hradci Kralove

OSTI ID:4084932

Dostal, M

The narcotic effect of intraperitoneally administered barbital and amobarbital sets is more rapidly in rats on the sixth day following irradiation with 600 r than in nonirradiated control rats. Duration of the narcotic effect on the sixth day after irradiation with 600 r is shortened by barbital and prolonged by amobarbital. X irradiation of rats with a dose of 600 r did not change the fairly uniform distribution of C/sup 14/ barbital administered intraperitoneally in indicator quantity together with a narcotic dose of soluble barbital. Greater activity of the urine recorded 2.5 hours following administration in rats on the third and sixth postirradiation day suggests that a shortened effect of barbital occurs most probably because of its accelerated elimination from the organism. The prolongation of the narcotic effect of amobarbital in irradiated rats may be caused by the postirradiation disorder of the liver because it does not occur after administration of barbital that is eliminated by the kidney without change. (auth)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-18-009922
• OSTI ID: 4084932
• Journal Information: Sb. Ved. Praci Lekar. Fak. Karlovy Univ. Hradci Kralove, Journal Name: Sb. Ved. Praci Lekar. Fak. Karlovy Univ. Hradci Kralove Vol. Vol: 6
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

AMYL RADICALS
ANESTHESIA
BARBITURIC ACID
BIOLOGY AND MEDICINE
CARBON 14
DISTRIBUTION
DRUGS
ETHYL RADICALS
KIDNEYS
LABELLED COMPOUNDS
LIVER
NERVOUS SYSTEM
PHYSIOLOGY
RADIATION DOSES
RADIATION EFFECTS
RATS
URINE
VARIATIONS
X RADIATION