Radiotoxicity of $sup 125$I in mammalian cells. I. Effects on the survival curve of radioiodine incorporated into DNA

Journal Article · Mon Dec 01 04:00:00 EST 1975 · Radiat. Res., v. 64, no. 3, pp. 555-563

OSTI ID:4080486

Bradley, E W; Chan, P C; Adelstein, S J

The effect of iodine-125 incorporated into the DNA of asynchronous, exponentially growing LICH cells as IUdR has been examined with regard to cell survival. A maximum of 33 to 129 disintegrations per nucleus resulted in cell replication failure as determined by clonal survival. Control experiments indicated that neither the chemical toxicity of the halogenated nucleoside nor the x rays due to iodine-125 in the extracellular medium played a role. Iodine- 131-labeled IUdR was much less toxic and mimicked Na $sup 131$I. The extreme toxicity of intranuclear iodine-125 appears to be due to the highly localized damage produced as a result of the Auger cascade. (auth)

• Research Organization: Harvard Medical School, Boston
• NSA Number: NSA-33-015035
• OSTI ID: 4080486
• Journal Information: Radiat. Res., v. 64, no. 3, pp. 555-563, Journal Name: Radiat. Res., v. 64, no. 3, pp. 555-563; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

*CELL CULTURES-- SURVIVAL TIME
*IODINE 125-- TOXICITY
560122* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Cells--Internal Source
ANIMAL CELLS
BIOLOGICAL RADIATION EFFECTS
DNA
N48220* --Life Sciences--Radiation Effects on Cells-- Internal Source
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