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Radiotoxicity of iodine-125 in mammalian cells. II. A comparative study on cell survival and cytogenetic responses to /sup 125/IUdR, /sup 131/IUdR, and /sup 3/HTdR

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3574422· OSTI ID:7339100
; ; ;
Hydrogen-3, iodine-125, or iodine-131 was incorporated into cellular DNA in the form of thymidine or its analog 5-iodo-2-deoxyuridine. The effects of these radionuclides on cell survival and chromosomes were examined in the V79 Chinese hamster cell line. It was found that in terms of cell killing, iodine-125 was considerably more effective than iodine-131 and hydrogen-3. The mean radioactivity contents at 37 percent survival were 0.10, 1.16, and 1.64 pCi per cell for iodine-125, iodine-131, and hydrogen-3, respectively. Similarly, iodine-125 was much more effective in inducing chromosome aberrations than iodine-131 or hydrogen-3. For example, 0.1 pCi per cell of iodine-125 gave rise to three chromosome breaks per cell; it took 1.0 pCi per cell of iodine-131 or 1.7 pCi per cell of hydrogen-3 to produce the same effect. The cytogenetic consequences of irradiation by these radionuclides, which decay by disparate processes, were directly related to their lethal effects and strengthens the theory that radiation-induced cell death results from damage in chromatin structures.
Research Organization:
Harvard Medical School, Boston
OSTI ID:
7339100
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 67:2; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560160* -- Radionuclide Effects
Kinetics
& Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIMETABOLITES
ANTIMITOTIC DRUGS
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL KILLING
CHROMOSOMAL ABERRATIONS
CHROMOSOME BREAKAGE
DAYS LIVING RADIOISOTOPES
DNA
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HAMSTERS
HETEROCYCLIC COMPOUNDS
HYDROGEN ISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE 131
IODINE ISOTOPES
IODODEOXYURIDINE
IODOURACILS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MUTATIONS
NUCLEI
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
RIBOSIDES
RODENTS
SURVIVAL TIME
THYMIDINE
TRITIUM
URACILS
VERTEBRATES
YEARS LIVING RADIOISOTOPES