RESISTANCE AND CROSS-RESISTANCE OF ESCHERICHIA COLI S MUTANTS TO THE RADIOMIMETIC AGENT PROFLAVINE

Journal Article · Sun Mar 01 00:00:00 EST 1964 · Journal of Bacteriology (U.S.)

OSTI ID:4078248

Woody-Karrer, P; Greenberg, J

All 50 of the first-step mutants of Escherichia coli S selected for resistance to proflavine were resistant to uv light and each of five different radiomimetic chemicals. The mutants were classified into eight types on the basis of their relative resistance to six different radiomimetic drugs and on the basis of the shape of their uv survival curves. Three of these types are identical to types previously isolated with other radiomimetic drugs; five of the types are new. A high proportion of the clones surviving proflavine treatment were phenotypically but not genetically resistant, and no strains were isolated which were resistant to proflavine but were not resistant to radiation. (auth)

• Research Organization: Palo Alto Medical Research Foundation, Calif.
• NSA Number: NSA-18-015844
• OSTI ID: 4078248
• Journal Information: Journal of Bacteriology (U.S.), Vol. Vol: 87; Other Information: Orig. Receipt Date: 31-DEC-64
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BACTERIA
DRUGS
ESCHERICHIA COLI
GENETICS
MUTATIONS
PROFLAVINE
RADIOMIMETIC DRUGS
RADIOSENSITIVITY
SENSITIVITY
ULTRAVIOLET RADIATION