THE EFFECTS OF ACUTE AND CHRONIC IRRADIATION ON THE RESPONSE OF THE DOG TO A HEMORRHAGIC STRESS

Journal Article · Tue Jan 01 04:00:00 EST 1963 · Texas Rept. Biol. Med.

OSTI ID:4077469

Knott, D H

Functional capacity of the cardiovascular system was studied in the irradiated dog. Dogs exposed to acute (500 r) and chronic (1 r/hr) doses of ionizing radiation were subsequently subjected to a standardized sublethal hemorrhagic stresss, consisting of a 100% bleed-out (bleeding volume) from a cannula in the femoral artery followed by the immediate re-infusion of a certain per cent of this bleeding volume. As an index of the volumetric and hemodynamic response to hemorrhage, the following parameters were determined: plasma and blood volumes, thiocyanate space, hematocrit, hemoglobin, cardiac output (dye- dilution technique), stroke volume, peripheral resistance, heart rate, blood pressure, and circulation time. In animals which were hemorrhaged on the fifth postirradiation day (500 r acute dose, x radiation) the volume of the vascular space was maintained more closely to normal after hemorrhage than that of the control group. However, the mean survival time of the irradiated group was significantly decreased. There was evidence also that another group of dogs hemorrhaged at 5 days postirradiation (500 r, acute) responded hemodynamically as well as, if not better than, the control group. (BBB)

• Research Organization: Univ. of Tennessee, Memphis
• NSA Number: NSA-18-015886
• OSTI ID: 4077469
• Journal Information: Texas Rept. Biol. Med., Journal Name: Texas Rept. Biol. Med. Vol. Vol: 21
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BLOOD
BLOOD CIRCULATION
BLOOD PLASMA
CYANIDES
DOGS
DYES
HEART
HEMATOCRIT
HEMOGLOBIN
HEMORRHAGE
ORGANIC SULFUR COMPOUNDS
PHYSIOLOGY
PRESSURE
QUANTITATIVE ANALYSIS
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
THIOCYANIDES
VOLUME
X RADIATION