AN EFFECTIVE THERAPEUTIC REGIMEN FOR THE HEMOPOIETIC PHASE OF THE ACUTE RADIATION SYNDROME IN DOGS

Journal Article · Tue Nov 01 04:00:00 EST 1960 · Radiation Research

DOI:https://doi.org/10.2307/3571030· OSTI ID:4118404

Sorensen, D K; Bond, V P; Cronkite, E P; Perman, V

A therapeutic regimen consisting in administration of large amounts of fresh whole blood when indicated to control bleeding, the judicious use of antibiotics to control infection, and parenteral fluids to combat dehydration was successful in reducing the mortatity from nine of ten untreated controls to two of ten in the treated group. The dogs were exposed to 400 r of h irradiation measured free in air at the position corresponding to the proximal skin surfface. It was found easier to control hemorrhage by fresh whole-blood transfusion than to control infection with antibiotice. Regeneration of the bone marrow as reflected by peripheral counts commenced on approximately the twenty-third to the thirtieth day postirradiation. The leukocytes appeared several days earlier than the platetets in all dogs. The rate of regeneration was different in the treated dogs and was slower in the four smaller dogs. The preirradiation-platelet, leukocyte, and red-blood-cell levels were not reached at the end of 100 days in these four dogs. The greater degree of effect seen in smaller dogs is discussed in terms of the greater tissue, or absorbed dose received by these animats with a given air-exposure dose. (auth)

• Research Organization: Brookhaven National Lab., Upton, N.Y.
• Sponsoring Organization: USDOE
• NSA Number: NSA-15-002538
• OSTI ID: 4118404
• Journal Information: Radiation Research, Journal Name: Radiation Research Vol. Vol: 13
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMALS
ANTIBIOTICS
BIOLOGY AND MEDICINE
BLOOD
BONE MARROW
ERYTHROCYTES
HEMORRHAGE
INFECTIONS
LEUCOCYTES
LIFETIME
MEDICINE
RADIATION PROTECTION
RADIATION SICKNESS
SKIN
TISSUES
X RADIATION