EFFECT OF HIGH PRESSURE OXYGEN ON RADIOSENSITIVITY OF EHRLICH'S TUMOR IN MICE AFTER "IMMUNOLOGICAL APPROXIMATION"
The effect of breathing high pressure oxygen (OHP) at 45 lb per square inch gauge pressure on radiosensitivity of Ehrlich's tumor (solid form) in vivo was studied. Recipient mice were given 400 r whole body irradiation before inoculation of tumor cells to cause immunological approximation and a substantial reduction in the homograft reaction. The effect of irradiation was based on cure of tumors 8 weeks after irradiation. Regression curves show that OHP caused a significant increase in radiosensitivity (radiocurability) with a dosage reduction by a factor of 2.4 ( plus or minus 0.5 SE). Tissue reactions assessed 4 weeks after irradiation were increased in OHP by factors ranging from 1.6 to 2.2. Evidence is provided that in mice breathing air at atmospheric pressure, tissue radiosensitivity approached levels corresponding to minimum (anaerobic) values: The results of polarographic measurements of oxygen tension in normal tissues and tumors in animals breathing air and OHP are described and discussed. (auth)
- Research Organization:
- Cancer Inst. Board, Melbourne
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-022008
- OSTI ID:
- 4071645
- Journal Information:
- Brit. J. Cancer, Journal Name: Brit. J. Cancer Vol. Vol: 15
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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