A COMPARISON OF THE CELL GENERATIVE CYCLE IN NORMAL, HYPERPLASTIC AND NEOPLASTIC MAMMARY GLAND OF THE C3H MOUSE
Technical Report
·
OSTI ID:4070284
The duration of the cell generative cycle is reduced in tumors of the manamary gland in comparison to normal alveolar cells and this, in all probability, plays a role in the dynamics of neoplastic growth. The hyperplastic preneoplastic cells show a generation time intermediate between those of normal and tumor cells. Factors other than an increased generative cycle rate are not excluded by these results. The duration of both the DNA synthetic period and the post-mitotic presynthetic period and possibly the post-synthetic premitotic period and mitosis decrease in neoplastic cells and in normal cell under hormonal stimulation. This result points out that the control of the cell cycle rate does not depend exclusively on variation of G/sub 1/. In fact, hormones as well as neoplastic transformation seem to act via a general mechanism that affects equally biochemical processes in the different phases of the cycle. (auth)
- Research Organization:
- Brookhaven National Lab., Upton, N.Y.; and Naples. Universita. Istituto di Patolige Generale
- DOE Contract Number:
- AT(30-2)-GEN-16
- NSA Number:
- NSA-18-021701
- OSTI ID:
- 4070284
- Report Number(s):
- BNL-7925; CONF-456-2
- Country of Publication:
- United States
- Language:
- English
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