A NEW EFFECT OF IONIZING RADIATION ON NUCLEOPROTEIN
An aqueous solution of nucleoprotein prepared from calf thymus was irradiated with high-energy electrons to a dose of 4 x lO/sup 6/ rads. Immediately following irradiation a white suspension collected at the bottom of the container. When irradiated and control solutions were analyzed, it was found that in addition to producing a precipitate, irradiation had degraded the amino acids, purine and pyrimidine bases, and desoxyrioose sugar. Analysis of the precipitate showed the presence of an acidic protein with purine and pyrimidine bases attached. The production of this precipitate by ionizing radiation confirms the presence of an acidic protein in the structure of nucleoprotein. The possible role of this precipitate in the biological effects of ionizing radiation is discussed. (C.H.)
- Research Organization:
- Royal Cancer Hospital, London
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-014143
- OSTI ID:
- 4067574
- Journal Information:
- Nature, Journal Name: Nature Vol. Vol: 189
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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