DISTRIBUTION OF RADIOACTIVE IODINE IN TUMOURS OF THE THYROID GLAND

Journal Article · Fri Jan 01 04:00:00 EST 1960 · Problems Oncol. (U.S.S.R.) (English Translation)

OSTI ID:4064012

Merkulov, M F; Modestov, V K; Maslov, N P; Poberii, I A

Results from an autoradiographic investigation into the distrioution of protein-bound compounds of radioactive iodine in ten thyroid gland tumors indicate absence of any fundamental difference in uptake of isotope as between malignant and benign tumors. There is a direct relation between the level of uptake of protein-bound iodine in individual tumors and the amount of intact follicular structure and their content of colloid. Iodinated proteins were not detected at the sites of dense cellular tumor growth. Large differences are noted in the level of uptake of protein-bound compounds of radioactive iodine among the different follicles. Uptake of radioactive iodine is as a rule inversely proportional to the size of the follicles. However, in thyroid gland tumors one may encounter not only large functioning but also small inactive follicles. The inequality of uptake radioactive iodine by the different follicles would suggest the existence of phasic changes in intrafollicular iodine metabolism. (auth)

• Research Organization: Central Medical Postgraduate Inst., Moscow; and Herzen State Oncological Inst., Moscow
• NSA Number: NSA-15-014100
• OSTI ID: 4064012
• Journal Information: Problems Oncol. (U.S.S.R.) (English Translation), Journal Name: Problems Oncol. (U.S.S.R.) (English Translation) Vol. Vol: 6
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
GLANDS
IODINE COMPOUNDS
IODINE ISOTOPES
METABOLISM
PROTEINS
RADIOAUTOGRAPHY
THYROID
TUMORS