Alterations within the rat thyroid gland during vitamin A deficiency
Thyroid glands from female rats kept vitamin A deficient for one, two, and three months were examined by electron microscopy. After one month on the diet, no consistent alterations were noted. After two months, the colloid in some follicles displayed a peripheral zone of decreased density. In addition, ultimobranchial follicles within the gland had become keratinized. After two to three months on the diet, cells were seen entering the colloid. Many of these cells were identified as follicular cells. Quantitative and autoradiographic studies indicated that thyroids of vitamin A deficient rats took up less radioiodide than thyroids of control rats. It's possible that the presence of follicular cells in the colloid reflects an accelerated turnover of these cells and could indicate an early pathological sign.
- Research Organization:
- Univ. of Maryland, Baltimore
- OSTI ID:
- 6719638
- Journal Information:
- Am. J. Anat.; (United States), Journal Name: Am. J. Anat.; (United States) Vol. 156:2; ISSN AJANA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACID PHOSPHATASE
ANIMALS
AUTORADIOGRAPHY
BODY
DISEASES
ELECTRON MICROSCOPY
ENDOCRINE GLANDS
ENZYMES
ESTERASES
GLANDS
HYDROLASES
IODINE ISOTOPES
ISOTOPES
MAMMALS
MICROSCOPY
MORPHOLOGICAL CHANGES
NEOPLASMS
NUTRITIONAL DEFICIENCY
ORGANS
PATHOGENESIS
PHOSPHATASES
RATS
RODENTS
THYROID
ULTRASTRUCTURAL CHANGES
UPTAKE
VERTEBRATES
VITAMIN A
VITAMINS