STUDIES ON THE METABOLISM OF Zr$sup 9$$sup 5$
Journal Article
·
· Kitakanko Igaku
OSTI ID:4058890
>The excretion and distribution of Zr/sup 95/ in rats of the ddstrain weighing about 20 g, and the influence of ZrOCl/sub 2/, CaEDTA, Na citrate, Na-Ca citrate, BAL, MgSO/sub 4/, and starvation were studied. The concentration of Zr/ sup 95/ injected subcutaneously and intraperitoneally was high in blood at the 6th hour, and afterwards concentrated in the bones. Excretion was most striking on the first day, 3.1% in urine and 5.9% in feces, with a 4-day total of 16.2%. At the end of the 4th day the distribution of Zr 5 was bone (11.7%) followed by kidney, blood, and liver in that order. When a large amount of ZrOCl/sub 2/ was used as a carrier, excretion appeared rather depressed, but when a small dose was used the opposite was true. After injection of EDTA intraperitoneally. excretion of Zr/sup 95/ increased. Zr/sup 95/ was slightly diminished in the bone and kidney, unchanged in the liver, and was increased in blood. Twenty-four hours after the oral administration of Ca-EDTA, increased excretion of Zr/sup 95/ was noted. The bone and kidney showed decreased and the liver increased retention. The subcutaneous injection of 0.2 ml of sodium citrate did not change the excretion of Zr/sup 95/, although 0.4 ml caused suppression, with some increase in the bone, liver, and kidney, and decrease in the blood. Oral sodium citrate caused no changes in excretion in spite of decreased bone retention. When 0.8 ml of Na-Ca citrate was injected subcutaneously a 2-fold increase in excretion was noted. No effect on excretion was prcduced by the injection of BAL. When MgSO/ sub 4/ was given orally 30 min after oral Zr/sup 95/, increased excretion and reduction of bone concentration resulted. During starwation the excretion of Zr/ sup 95/ was depressed and there was increased retention in the liver, but no change in the bone and blood content. (Absts. Japan. Med., 1: No. 6, 1961)
- Research Organization:
- First National Hospital, Tokyo
- NSA Number:
- NSA-15-023261
- OSTI ID:
- 4058890
- Journal Information:
- Kitakanko Igaku, Journal Name: Kitakanko Igaku Vol. Vol: 9
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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