REACTION OF THE THYROID GLAND TO SINGLE ADMINISTRATION OF $sup 210$Po (in Russian)
Fifty-one male white rats, weighing 150 g, were given /sup 10/Po in the amount of 0.02 mu C/kg, which is lethal in 150 days. With time, the weight of the thyroid increased, both absolute and relative. Morphological changes were typical of those found in hyperplasia: thicker epithelium, narrower follicles, more colloid resorption, and wider interfollicular capillaries. These were observed on the tenth day, and on the 40th, 70th, and 100th days were observed to have increased progressively. The uptake of /sup 131/I by the gland on the tenth day was no different from that in normal animals, but on the 40th day had sharply changed. The curve for /sup 131/I absorption by the gland on days 40 to 42 was characterized by a peak at 1 to 8 hr, followed by a rather steep drop. The curve at days 100 to 102 was more like the control in shape but was lower. The noncorrespondence between morphology and function at the later times may be the result of direct damage to the thyroid gland tissue, caused by the Po/sup 210/, but is more probably due to a functional depletion of the thyroid with hyperstimulation of the thyreotropic hormone of the hypophysis. (TTT)
- Research Organization:
- Inst. of Biophysics, Moscow
- NSA Number:
- NSA-18-017593
- OSTI ID:
- 4056443
- Journal Information:
- Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.), Journal Name: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.) Vol. Vol: 4; ISSN RADOA
- Country of Publication:
- Country unknown/Code not available
- Language:
- Russian
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