THE RADIOBIOLOGICAL EFFECT OF DIFFEREENT DOSE RATES: A STUDY OF WHOLE BODY EXPOSURE OF MICE TO Co$sup 60$$gamma$-RAY

Journal Article · Thu Jan 01 04:00:00 EST 1959 · Nippon Igaku Hoshasen Gakkai Zasshi (Japan)

OSTI ID:4048148

Kusumoto, G

Adult male mice were irradiated by a series of 4 diffent dose rates, ranging from 9.5 to 92.4 r/min, using a 1000-c Co/sup 6//sup 0/ source. LD/sub 5//sub 0/ for each of the 4 dose rates showed a significant difference; the higher the dose rate, the lower the LD/sub 5//sub 0/. The survival rate also decreased with an increase of dose rate, when mice were exposed to total-body irradiation of 800 r. Pathological changes were studied using mice irradiated by 800 r of Co/sup 6//sup 0/ gamma ray with dose rates of 85.6 and 9.5 r/min. In a case of higher dose rate, histological damages occurred earlier and more intensively, while regenerative changes were delayed as compared with lower dose rate, the differences being most conspicuous in the bone marrow and spleen. (Absts. Japan. Med., 1: No. 7, 1960.)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-15-022102
• OSTI ID: 4048148
• Journal Information: Nippon Igaku Hoshasen Gakkai Zasshi (Japan), Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi (Japan) Vol. Vol: 19; ISSN NHGZA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BODY
BONE MARROW
COBALT 60
GAMMA RADIATION
GLANDS
IRRADIATION
LETHAL DOSE
LIFETIME
MICE
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
REGENERATION
SPLEEN
WHOLE-BODY IRRADIATION