EFFECTS OF WHOLE BODY X-IRRADIATION ON IRON METABOLISM
Serum iron (SI) and percent-utilization of radioactive iron by the erythrocytes were determined following single and daily whole-body x irradiation in varying doses to male rabbits. SI and unsaturated iron binding capacity (UIBC) of x-ray technicians were measured in 1953 and 1957. Transient decrease of SI was observed from 6 to 24 hr and the lowest value appeared at 12 hr after the single x irradiation; thereafter, SI reached its maximum at 48 or 72 hr. The greater the single dose, the more marked was the fluctuation of SI. Daily exposure to x rays for 4 weeks caused a gradual increase of SI in the animals which received more than 12.5 r, and the greater the dally doses, the more marked the increase of SI. The elevated level of SI began to decrease after the suspension of daily irradiation for 4 weeks, and the greater the doses, the slower the recovery from the increased SI. Decrease of percent utilization of radioactive iron by erythrocytes was marked after the single as well as after the daily irradiation. Effects of daily exposure to a small dose of x rays were similar to those of a greater dose of single irradiation. The increase of SI and decrease of percent-utilization of radioactive iron would be due to the obstruction of hematopoiesis following whole-body x irradiation. Trends of increase of SI and decrease of UIBC of x-ray technicians were observed in 1953. Differences in SI and UDBC between x-ray technicians and normal control persons were insignificant in 1953 and 1956. (Absts. Japan. Med., 1: No. 7, 1960.)
- Research Organization:
- Nagoya Univ., Japan
- NSA Number:
- NSA-15-022108
- OSTI ID:
- 4048112
- Journal Information:
- Nippon Igaku Hoshasen Gakkai Zasshi (Japan), Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi (Japan) Vol. Vol: 19; ISSN NHGZA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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