EXPERIMENTAL STUDIES ON THE EFFECT OF X-RAY IRRADIATION TO THE HEADS OF MICE
Journal Article
·
· Kitakanko Igaku
OSTI ID:4044447
The heads of male mice weighing 20 to 23 g were irradiated with x rays in a dose of 2 x 10/sup 4/ r. Test chemicals were administered before and after the irradiation. Characteristic neurological signs caused by irradiation, such as epileptic convulsions, were observed. The survival times of the animals were recorded, and the histological changes of the brain tissues were studied. Cysteine snd also chlorothiszide had a protective effect sgainst both the neurological signs and the fatal damage to the brain caused by the irradiation, but NaCN had little effect. Chlorpromazine protected against the former but was ineffective against the latter. Soluble barbital, urethan, diphenylhydantoin, promethazine, caffeine-sodium benzoate, and camphor had similar effects as chlorpromazine. Morphine hydrochloride had some protective effect against both. The effect of sodium thiopental, DOCA, and magnesium sulfate was similar to that of morphine-HCl. Vasopressin enhanced the damage to a certain degree. No definite parallelism was seen between the effects of the drugs on the neurological signs produced by irradiation and the lethal rate. The effect of the chemicals on the fatal injuries varied with the doses injected. It is consequently considered that dehydration in the brain tissues was probably an important factor in the fatal cases. (Absts. Japan. Med., 1: No. 7, 1960.)
- Research Organization:
- Gunma Univ., Maebashi, Japan
- NSA Number:
- NSA-15-022053
- OSTI ID:
- 4044447
- Journal Information:
- Kitakanko Igaku, Journal Name: Kitakanko Igaku Vol. Vol: 9
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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