PROTECTIVE EFFECT OF ARTIFICIALLY INDUCED HIBERNATION AGAINST LETHAL DOSES OF WHOLE BODY X-IRRADIATION IN CF$sub 1$ MALE MICE

Journal Article · Mon Jun 01 04:00:00 EDT 1959 · American Journal of Physiology (U.S.)

OSTI ID:4255164

Kuskin, S M; Wang, S C; Rugh, R

Hypothermia induced by the use of neuroplegic drugs such as Hydergine, chlorpromazine, or promethazine, followed by refrigeration, does not significantly enhance the protective action afforded by refrigeration alonc against the lethal dose of whole body x-irradiation in CF/sub 1/ male mice. The neuroplegic drugs, without refrigeration, provide a slight degree of protection, probably due to the slight reduction in the body temperature. It appears that the action of hypothermia as a protective mechanism depends not on depression of metabolism alone, but on a general depression of bodily processes. Urethane, in conjunction with refrigeration, appears to augment the lethal effect of x- irradiation in the CF/sub 1/ strain of male mice. (auth)

• Research Organization: Columbia Univ., New York
• NSA Number: NSA-13-014153
• OSTI ID: 4255164
• Journal Information: American Journal of Physiology (U.S.), Journal Name: American Journal of Physiology (U.S.) Vol. Vol: 196; ISSN AJPHA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AMINES
BIOLOGY AND MEDICINE
BODY
CARBAMATES
CHLORPROMAZINE
DRUGS
ETHYL RADICALS
HETEROCYCLICS
HIBERNATION
LETHAL DOSE
METABOLISM
METHYL RADICALS
NERVOUS SYSTEM
ORGANIC CHLORINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PHENOTHIAZINES
PROPYL RADICALS
RADIATION INJURIES
RADIATION PROTECTION
RADIOSENSITIVITY
TEMPERATURE
URETHANE
VARIATIONS
X RADIATION