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The Relative Genetic Radio-Sensitivity of Various Species of Mammals and of Drosophila; OTNOSITEL'NAYA GENETICHESKAYA RADIOCHUVSTVITEL'NOST RAZLICHNYKH VIDOV MLEKOPITAYUSCHIKH I DROZOFILY

Technical Report ·
OSTI ID:4040845
; ; ;
Tests were made with 2.5- to 4-month-old white mice and rats weighing 19 to 25 g and 190 to 250 g respectively and 5- to 8-month-old rabbits of 3 to 4 kg. The mice were exposed to local (testis) irradiations of 134, 268, 402, and 670 r at 36 to 40 r/min; the rats to 134, 268, and 750 r; and the rabbits to 150, 300, 450, 600, and 750 r. Embryo deaths in non-exposed females mated to irradiated males were tabulated and analyzed as dominant lethals developed in male spermatozoid. The genetic radiosensitivity of the animals is expressed by the following sequence: mice < rats < rabbits. The genetic radiosensitivity in rabbits is about 1.5 to 2.5 times that in mice. Moreover, in contrast to mice and rats the induced dominant lethals in most cases caused the destruction of embryos before the implantation, while in mice and rats they perished after embryo implantation. The comparative evaluation of genetic radiosensitivity in mice and Drosophila, determined by dominant lethals, shows mice are 5 to 10 times more radiosensitive. The frequency of dominant lethals in mice and Drosophila is proportional to the general size of the compared chromosomes. (R.V.J.)
Research Organization:
Akademiya Nauk S.S.S.R.
NSA Number:
NSA-15-015399
OSTI ID:
4040845
Report Number(s):
A/AC.82/G/L.415
Country of Publication:
Country unknown/Code not available
Language:
English

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Related Subjects

ANIMALS
BIOLOGY AND MEDICINE
CHROMOSOMES
DROSOPHILA
EMBRYOS
GENETICS
INSECTS
MICE
RABBITS
RADIOSENSITIVITY
RATS