REGRESSION OF GRAFTED BONE MARROW IN HOMOLOGOUS IRRADIATED MOUSE CHIMERAS

Journal Article · Wed Mar 01 04:00:00 EST 1961 · Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst.

DOI:https://doi.org/10.1097/00006534-196110000-00060· OSTI ID:4040516

Popp, R A

Lethally irradiated mice receiving injections of bone marrow exhibited only a transitory production of graftderived erythrocytes, the tendency for regression of the grafted marrow apparently varying with the x-ray dose and number of marrow cells infused. Judged on the basis of circulating erythrocytes, the grafted marrow persisted longer and regressions occurred later and less frequently in lethally than in midlethally irradiated recipients of 75 x 10/sup 6/ cells. Regression of grafted 101 marrow was not observed in lethally irradiated mice, though such marrow did regress in midlethally irradiated hybrid recipients. The delayed montality of the irradiated recipients was not consistently correlated with persistence or regression of the grafted marrow. The regression of grafted parental marrow noted under these conditions cannot as yet be conclusively explained, but might have resulted from an immunological rejection of the grafted cells. Genetic mechanisms for such a phenomenon are discussed, along with other mechanisms that might favor the selective growth of autologous hematopoietic cells. (auth)

• Research Organization: Oak Ridge National Lab., Tenn.
• Sponsoring Organization: USDOE
• NSA Number: NSA-15-015442
• OSTI ID: 4040516
• Journal Information: Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst., Journal Name: Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst. Vol. Vol: 26; ISSN JNCIA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
BONE MARROW
CHIMERAS
ERYTHROCYTES
GENETICS
IMMUNITY
LETHAL DOSE
MICE
RADIATION INJURIES
RADIATION PROTECTION
TRANSPLANTS
X RADIATION