ACCEPTANCE OF RAT AND MOUSE LUNG GRAFTS BY RADIATION CHIMERAS
Technical Report
·
OSTI ID:4185021
Rat-mouse bone marrow chimeras, i.e., lethally xirradiated minice which had been injected with rat bone marrow, were given grafts of rat and mouse lung tissue, by subcutaneous implantation at 14 to 270 days postirradiation. The lung grafts were removed 35 to 40 days after implantation, fixed in formalin, and the histological sections examined microscopically for evidence of growth and persistence of the graft, or of rejection. In normal non-irradiated mice or in isologous chimeras, the mouse lung grafts grew well in 73% of the recipients, while rat lung grafts were rejected in 100% of the animals. In the heterologous chimeras, rat lung grew well in 56% of the animals, while mouse lung grew well in only 19% (16 mice, 14 tc 39 days post irradiation). In heterologous chimeras (19 mice) grafted 55 to 270 days post-irradiation, rat lung grafts grew well in 58%, and mouse lung in 69% of the mice. In one chimera which lost its rat marrow graft at 60 days post-irradiation (as evidenced by the absence of alkalinephosphatase positive rat granulocytes in the peripheral blood), mouse lung grew well, but rat lung was rejected. The significance of these observations, with respect to the immunological status of rat-mouse chimeras, and the problem of secondary disease was discussed. (auth)
- Research Organization:
- Naval Radiological Defense Lab., San Francisco
- NSA Number:
- NSA-14-006085
- OSTI ID:
- 4185021
- Report Number(s):
- USNRDL-TR-376
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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