PHARAMACOLOGICAL STUDIES ON IRRADIATED ANIMALS. VIII. SOME PAPER CHROMATOGRAPHIC ANALYSES OF CELL-FREE SPLEEN EXTRACTS PROTECTING AGAINST RADIATION DEATH. Research Report No. 3

Technical Report · Wed Jan 27 04:00:00 EST 1960

OSTI ID:4040493

Henderson, N; Ellinger, F

Paper chromatographic studies on cell-free saline extracts from the spleens of mice, guinea pigs, rabbits, and dogs were performed as a first step in the chemical isolation and identification of a common principle or principles of these spleen extracts which might explain their protective action against radiation induced death. These studies were performed on lyophilized and fresh extracts, the water-soluble and -insoluble fractions of dialyzed extracts, and the diffusate after dialysis. Pertinent findings concerning identification of 18 amino acids and 5 carbohydrates are reported. The variations observed in the chemical composition of these various spleen extracts offer valuable leads for further studies. (auth)

• Research Organization: Naval Medical Research Inst., Bethesda, Md.
• NSA Number: NSA-15-015462
• OSTI ID: 4040493
• Report Number(s): NP-9950; DASA-516 Pt.8
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AMINO ACIDS
ANIMALS
BIOLOGY AND MEDICINE
CARBOHYDRATES
CHROMATOGRAPHY
DOGS
GLANDS
GUINEA PIGS
MICE
PHARMACOLOGY
RABBITS
RADIATION PROTECTION
RADIATION SICKNESS
SPLEEN