LYSOSOME PARTICLES AND SUBCELLULAR DISTRIBUTIONS OF POLYMERIC TETRAVALENT PLUTONIUM-239
Tissue fractionation studies were made of livers of rats 1, 8, and 28 days after they received a single irtravenous injection of 0.5 mu C of polymeric Pu, /sup 239/Pa(IV). The subcellular distribution of the Pu was found to be nearly identical with the distribution of the acid phosphatase, indicating concentration of Pu in the lysosomal fraction. On the basis of the release of acid phosphatase from liver lysosomes, no difference in sensitivity to a nonionic detergent, Igepal-630, was found between the lysosomes of rats receiving plutonium and of uninjected controls for at least 14 days after Pu injection. (auth)
- Research Organization:
- Argonne National Lab., Ill.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-18-019669
- OSTI ID:
- 4036977
- Journal Information:
- Radiation Res., Journal Name: Radiation Res. Vol. Vol: 21
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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