NEURO-GUMORALE SUBSTANCES OF DOG BLOOD DURING ACUTE RADIATION SICKNESS. I. CHANGES IN BLOOD ACETYLCHOLINE AND CHOLINESTERASE SYSTEM (in Russian)
Experiments carried out on 13 male dogs, 2 to 5 years old and weighing 10 to 20 kg, showed that in the initial stages of chroric radiation sickness the blood content of acetylcholine increased and the cholinesterase decreased. Moreove r, the increase in the acetylcholine level during the first 3 to 4 hrs proceeded at a greater rate than the cholinesterase decrease. Shifts in the enzyme system were more pronounced in dogs with greater resistance. However, during the recovery period acetylcholine and cholinesterase restoration took place at earlier periods in dogs with higher resistance. Not only was the cholinesterase activity restored, but it increased to 1.5 to 2 times the initial level. The level of acetylcholine and cholinesterase was not restored in the blood of dogs during terminal periods. In dogs exposed to subacute doses, 300 r, enzyme normalization took place 29 to 41 days following exposure. Correlation of data on enzyme changes in single and chronic exposures indicated identical trends It was postulated that acetylcholine -cholinesterase participate in compensating reactions of organisms during radiation sickness. (R.V.J.)
- Research Organization:
- Inst. of Neurology, Moscow
- NSA Number:
- NSA-18-019683
- OSTI ID:
- 4036849
- Journal Information:
- Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.), Vol. Vol: 3; Other Information: Orig. Receipt Date: 31-DEC-64
- Country of Publication:
- Country unknown/Code not available
- Language:
- Russian
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