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CHANGES OF NEUROHUMORAL SUBSTANCES OF THE BLOOD DURING THE DEVELOPMENT OF EXPERIMENTAL CHRONIC RADIATION SICKNESS (in Russian)

Journal Article · · Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR
OSTI ID:4151255
The results are presented for studies on the dynamics of acstylcholine and the activity of cholinesterase, histamine, adrenaline of the blood of dogs during the development of chronic radiation sickness, induced by repeated and numerous action of fractional doses of ionizing radiation. The irradiation was instituted daily at a dose of 15 r with two RUM-3 apparatus, with a capacity of 7 to 8 r/min. The substances were investigated before and after the irradiation, once or twice weekly throughout the course of chronic radiation sickness (4 to 6 months). The most acute changes are found in the initial stage of chronic radiation sickness. They are characterized by: a rise of acetylcholine content; a drop of cholinesterase activity; an elevation of the histamine content; an increase of the content of adrenalinelike substances at the beginning with its subsequent diminution; and a rise of adrenaline. Then there are observed unduating changes in the content of neurohumoral substances of the blood which are manifested by insignificant variations near the initial level. Changes of the neurohumoral substances of the blood in a pronounced clinical picture are expressed by: a rise of acetylcholine; a drop of cholinesterase activity; an increase of histamine level; and inconsiderable fluctuations in the content of adrenalinelike substances. At the terminal stage the acetylcholine level in the blood remains elevated with a further reduction of cholinesterase activity. The histamine content remains increased or even rises higher; the values of adrenalinelike substances fluctuate within the limits of the initial level. (auth)
Research Organization:
Inst. of Neurology, Academy of Medical Sciences, USSR
NSA Number:
NSA-15-002529
OSTI ID:
4151255
Journal Information:
Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR, Journal Name: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR Vol. Vol: 5, No. 9; ISSN MERAA
Country of Publication:
Country unknown/Code not available
Language:
Russian

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Related Subjects

ANIMALS
BIOLOGY AND MEDICINE
BLOOD
ENZYMES
HORMONES
RADIATION SICKNESS
RADIATIONS