THE REACTIVITY OF THE HEART TO CERTAIN PHARMACOLOGICAL AGENTS IN RABBITS AFFECTED WITH POLONIUM (ELECTROCARDIOGRAPHIC DATA)

Journal Article · Mon Feb 01 04:00:00 EST 1960 · Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR

OSTI ID:4145880

Moroz, B B; Grozdou, S P

Electrocardiographic data are presented on the reaction of the myocardium to adrenaline, carbocholine, ephedrin, and nitroglycerin in rabbits at different stages of acute radiation sickness induced by polonium. There were divulged changes in the excitability and conductivity of the myocardium in which two developmental stages could be distinguished. In the first stage the sensitivity of the heart was elevated. After the introduction of adrenaline, bradycardia intensified, exrasystoles were observed more often and ventricular flutter and heterotopic ventricular rhythm. was observed. The administration of carbocholine produced a sharper retardation of atrioventricular conductivity, even an incomplete block of the II to III degree, etc. In the second stage, as compared with the early periods of radiation sickness, a drop of cardiac sensitivity was observed. The reactivity of the heart to adrenaline, carbocholine, and nitroglycerin, especially at late stages, was considerably reduced or the myocardial reaction was absent completely. At the peak of radiation sickness marked changes of the electrocardiogram were seen which were indicative of dystrophic processes in the myocardium (a drop of the wave P amplitude and QRS complex, a rise and a sharpening of T wave a lengthening of the QRST complex, and displacement of the isoelectric axis to the right). An elevated sensitivity of the heart during the first stage was apparently associated with disturbances of extracardiac innervation, especially with the increase of parasympathetic influences. A diminution of the cardiac reaction in the second stage was possibly due to a weakening of extracardiac reflexes and affection of the cardiac muscle as well. (auth)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-14-012511
• OSTI ID: 4145880
• Journal Information: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR, Journal Name: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR Vol. Vol: 5, No. 2; ISSN MERAA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

ADRENAL GLANDS
ADRENALINE
ALCOHOLS
ALKALOIDS
BIOLOGY AND MEDICINE
DETECTION
DISEASES
DRUGS
ELECTRIC METERS
ELECTRIC POTENTIAL
ELECTROCARDIOGRAPHY
EPHEDRINE
HEART
HORMONES
MUSCLES
NERVOUS SYSTEM
ORGANIC NITROGEN COMPOUNDS
PHYSIOLOGY
POLONIUM
RABBITS
RADIATION EFFECTS
RADIATION SICKNESS
VARIATIONS