INFLUENCE OF 19 NORANDROSTENOLONE PHENYLPROPIONATE ON RECOVERY IN TOTALLY IRRADIATED ANIMALS

Journal Article · Tue Dec 31 04:00:00 EST 1963 · Boll. Soc. Ital. Biol. Sper.

OSTI ID:4036503

Caprino, G; Gallina, F

Doses of 10 mg/kg of 19-norandrostenolone phenyl propionate were administered parenterally to adult rats for three days before total-body x irradiation and for four days afterwards. The irradiation doses were 400 r and 600 r. Female rats were used, since steroids with androgenic activity cause a mortality increase in male rats when administered after irradiation. Five lots of 10 animals were used; the first was treated only with the steroid, the second was irradiated with 600 r, the third irradiated and treated with the steroid. The fourth and and fifth lots were similar to the second and third except that a 400-r irradiation dose was used. The animais treated solely with the steroid showed a significant increase in wt which continued even after the end of treatment. The animals irradiated with 600 r died between the 5th and 10th day after treatment and showed a rapid loss in body wt. In the third group, eight died before the 12th day after a steady loss of wt; one died on the 18th day after.losing wt less rapidly than the animals which were only irradiated, and one died on the 32nd day after regaining initial wt. Haif of the animals irradiated with 400 r died between the 7th and 13th day after progressive loss of wt (intestinal death), while the other had a slight decrease in body wt and died between the 14th and 19th day (hemopoietic death). Those irradiated with 400 r and treated with the drug showed wt loss for three days; four of these died between the 7th and 12th days with progressive wt loss; three died between the 14th and 24th day, and two of these with greater than initial wt; and three survived with increased body wt. (BBB)

• Research Organization: Universita, Perugia, Italy
• NSA Number: NSA-18-019779
• OSTI ID: 4036503
• Journal Information: Boll. Soc. Ital. Biol. Sper., Journal Name: Boll. Soc. Ital. Biol. Sper. Vol. Vol: 39
• Country of Publication: Country unknown/Code not available
• Language: Italian

Related Subjects

AGE
BIOLOGY AND MEDICINE
BODY
DRUGS
HORMONES
IRRADIATION
LETHAL DOSE
PERFORMANCE
RADIATION DOSES
RADIATION PROTECTION
RADIATION SICKNESS
RATS
SEX
STANDARDS
STEROIDS
SURVIVAL TIME
TESTING
VARIATIONS
WEIGHT
X RADIATION