THE ROLE OF ADRENAL CORTICAL HORMONES IN X RAY-INDUCED LIVER CHANGES

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Acta Medica Academiae Scientiarum Hungaricae (Hungary)

OSTI ID:4829287

Stark, E; Zadory, E; Lapis, K

Total-body irradiation of rats with 600 r produced severe degenerative lesions in liver which were evident by the 6th or 7th day. A dose of 400 r had no visible effects on liver and 500 r produced slight changes in some animals, seen as fat accumulation at the periphery of liver lobules. At the 600-r dose the following histopathologic changes were seen in liver: separation of trabeculae and dilatation of sinusoids in central portions of lobules, severe fatty infiltration at the center of lobules, and desquamation of sinusoid endothelial cells. In adrenalectomized rats, maintained on deoxycorticosterone acetate (DOCA), 600 r failed to produce any liver lesions in -- half of the animals and fatty degeneration was mild in the remainder. In these animals, irradiation appeared to have no effect on the spleen and lymph nodes, which underwent hypotrophy as a result of adrenalectomy. In adrenalectomized rats treated with 1.5 mg/day hydrocortisone in addition to DOCA, irradiation produced the same liver lesions as in irradiated controls. Thus, glucocorticoid hormone appears to sensitize the liver to radiation injury. (H.H.D.)

• Research Organization: Medical Univ., Budapest
• NSA Number: NSA-16-020247
• OSTI ID: 4829287
• Journal Information: Acta Medica Academiae Scientiarum Hungaricae (Hungary), Journal Name: Acta Medica Academiae Scientiarum Hungaricae (Hungary) Vol. Vol: 18; ISSN AMASA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ADRENAL GLANDS
ANIMAL CELLS
BIOLOGY AND MEDICINE
BODY
CORTISONE
CYTOLOGY
HORMONES
LIVER
LYMPH NODES
LYMPH SYSTEM
MICROSCOPY
QUANTITY RATIO
RADIATION DOSES
RADIATION INJURIES
RADIOSENSITIVITY
RATS
SPLEEN
STEROIDS
SURGERY
X RADIATION