X-IRRADIATION PROTECTION STUDIES. II. MODIFICATION OF THE RADIATION SYNDROME IN FEMALE DAL-SWISS MICE BY AET AND 5-HT

Technical Report · Wed Mar 29 04:00:00 EST 1961

OSTI ID:4035399

Leitch, J L

To evaluate the efficiency of aminoethylisothiuronium bromide-HBr (AET) and 5-hydroxytryptamine (5-HT) for the modification of the radiation syndrome, female DALSwiss mice were exposed to doses of 460 to 1200 r of whole-body x irradiation. The survival time curves were analyzed by the graphical method of Litchfield. The dose rate was also varied in one experiment. It has been shown that a combined intraperitoneal dose of 10 mu M AET plus 1 mu M 5-HT prior to a single whole-body 460 r x ray exposure given in a 35 minute period decreased the total cumulative per cent mortality and increased the survival time to a greater extent than did either compound when used alone. This dose of AET + 5-HT increased the ST/sub 50/ time from 7.2 days to 40 days and decreased the 60-day mortality from 95.8 to 48.6%, respectively. A dose of 1200 r x rays was required to reduce the ST/sub 50/ time of treated mice from 40 to 6.6 days, a value approximately equal to that for untreated mice receiving only 460 r. If the 460 r whole-body x-ray dose was given in approximately 7.5 hours no protection could be demonstrated. (auth)

• Research Organization: California. Univ., Los Angeles. School of Medicine
• NSA Number: NSA-15-015414
• OSTI ID: 4035399
• Report Number(s): UCLA-472
• Country of Publication: United States
• Language: English

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BIOLOGY AND MEDICINE