Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

STUDIES ON CHEMICAL PROTECTION AGAINST RADIATION INJURY. IV. EFFECT OF RESERPINE AND 5-HYDROXYTRYPTAMINE

Journal Article · · Nippon Igaku Hoshasen Gakkai Zasshi (Japan)
OSTI ID:4040629
Reserpine and 5-hydroxytryptamine (5-HT) were injected into the peritoneal cavity of mice before whole-body x irradiation of 800 r or 680 r. The survival rate 30 days after irradiation and change in body weight were noted. Reserpine showed a slight protective effect, not sex-dependent. 5-HT showed a protective effect in the female rather than in the male, in a dose of 4 mg/kg given 24 hr before x irradiation. In the group given 5 mg/kg of 5-HT, 30 min before irradiation, the protective effect depended on the radiation dose delivered. The protective effect of these agents may be due to depressed oxidation-reduction metabolism in the CNS. (Absts. Japan. Med., 1: No. 6, 1961)
Research Organization:
Kyoto Univ.
NSA Number:
NSA-15-023358
OSTI ID:
4040629
Journal Information:
Nippon Igaku Hoshasen Gakkai Zasshi (Japan), Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi (Japan) Vol. Vol: 19; ISSN NHGZA
Country of Publication:
Country unknown/Code not available
Language:
English