LEUKEMIA AND RETICULAR NEOPLASMS IN THE MOUSE AFTER INTERMITTENT IRRADIATION

Journal Article · Sat Apr 01 04:00:00 EST 1961 · Radiation Research

DOI:https://doi.org/10.2307/3570989· OSTI ID:4026066

Duhig, J T; Warren, S

The effects of varying total doses of intermittent totalbody x irradiation on the development of tumors of the reticuloendothelial system of A strain mice are reported. Three main groups were distinguished: (l) generalized lymphoid leukemia or lymphosarcoma, (2) myeloid leukemia, and (3) localized reticular neoplasms. The only reticular tumor seen in control mice with any frequency was a generalized lymphoid leukemia without thymic enlargement. Radiation resulted in a marked increase in incidence of lymphoid leukemia with thymic enlargement. Lymphoid leukemia without thymic enlargement was little affected by radiation. A number of mice showed aplastic or hypolastic bone marrows, predominantly those with lymphoid leukemia and significantly more in female mice and animals with nonthymic lymphoid leukemia. It is suggested that depression of lymphocytes and myaloid cells may be an important factor in the pathogenesis of lymphoid leukemia after irradiation. Myaloid leukemia and localized reticular neoplasms were rare in these mice. Their incident appeared to be increased after radiation, consistent with the increase in all types of tumors observed in the irradiated animals. (auth)

• Research Organization: New England Deaconess Hospital, Boston
• Sponsoring Organization: USDOE
• NSA Number: NSA-15-016847
• OSTI ID: 4026066
• Journal Information: Radiation Research, Journal Name: Radiation Research Vol. Vol: 14
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BONE MARROW
CARCINOGENESIS
GLANDS
IRRADIATION
LEUKEMIA
LYMPH SYSTEM
LYMPHOCYTES
MICE
RADIATION EFFECTS
RETICULOENDOTHELIAL SYSTEM
THYMUS
TUMORS
X RADIATION