STUDIES ON ANAPHYLACTIC SHOCK IN THE MOUSE. III. EFFECTS OF SINGLE WHOLE- BODY X-IRRADIATION OF 500 ROENTGENS
The effects of x irradiation (500 r) on the anaphylactic response of mice sensitized with bovine albumin-adjuvant emulsion and challenged with bovine albumin solution were studied. X irradiation given 0.125. 2, 4, 6, or 9 days before or 2, 4, or 6 days following sensitization failed to enhance the anaphylactic sensitivity when the interval between sensitization and challenge was 7 days. X irradiation given days after sensitization depressed the anaphylactic sensitivity of mice challenged 10 days after sensitization as measured by mortality incidence and changes in rectal temperatures. In general, a depressive effect of x irradiation on the anaphylactic response was observed in mice exposed 2, 4, 6, 8, or 10 days prior to or 2 days following sensitization when challenge was made 14, 21, 28, 35, or 42 days postsensitization. An enhancement of susceptibility to fatal anaphylaxis was discernible in sensitized animals receiving x irradiation 4 days or more following sensitization when the interval between sensitization and challenge was 14, 21, or 28 days. No effect of x ray on mortality incidence or change in rectal temperature was observed when the interval was 35 or 42 days. (auth)
- Research Organization:
- Univ. of Kansas School of Medicine, Kansas City; and Univ. of Kansas, Lawrence
- NSA Number:
- NSA-15-016841
- OSTI ID:
- 4026027
- Journal Information:
- Journal of Immunology (U.S.), Journal Name: Journal of Immunology (U.S.) Vol. Vol: 84; ISSN JOIMA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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