SYNTHESIS: BIOLOGICAL HALF-LIFE, ELECTROPHORETIC PATTERNS, AND CONCENTRATION OF RAT SERUM PROTEINS AFTER X-IRRADIATION
The changes in concentration of various serum protein fractions in rats after 3000 of whole-body x irradiation were studied. Pre- and post-treatment serum samples from the same animal were separated by paper strip electrophoresis. The ratios of% post- to% pre-treatment values were compared for starved controls, fed controls, irradiated animals, spleen-shielded animals, liver-shielded animals, and spleen and liver-shielded animals. (A percentage figure refers to the % of total serum protein found in any particular fraction). The data indicated a disturbance in synthesis following irradiation but did not exclude an alteration in biological haif life of the various fractions. The incorporation of /sup 35/-labeled L-methionine into serum proteins was studied using 12 starved rats as controls and 12 whole-body-irradiated rats. The data indicated an increase in synthesis rates when serum protein fraction concentrations were increased ( alpha /sub 1/-, alpha /sub 2/-, and BETA -giobulins) and a decrease in synthesis rates when serum protein fractions were decreased ( gamma -globulin and albumin). Additional experiments indicated that the biological half lives of the various serum protein fractions were not altered by irradiation. (Dissertation Abstr., 24: No. 8, Feb. 1964)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-18-019754
- OSTI ID:
- 4022483
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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Related Subjects
AMINO ACIDS
BIOLOGY AND MEDICINE
BLOOD SERUM
BODY
ELECTROPHORESIS
GLOBULINS
IRRADIATION
LABELLED COMPOUNDS
LIVER
METABOLISM
METHIONINE
NUMERICALS
ORGANIC SULFUR COMPOUNDS
PERFORMANCE
PROTEINS
RADIATION DOSES
RADIATION EFFECTS
RADIOBIOLOGY
RADIOSENSITIVITY
RATS
SHIELDING
SPLEEN
STANDARDS
STATISTICS
SULFUR 35
TESTING
TRACER TECHNIQUES
X RADIATION