ALTERATIONS IN SERUM LYSOZYME AND PROPERDIN TITERS OF MICE FOLLOWING X- IRRADIATION OR TREATMENT WITH ZYMOSAN OR ENDOTOXIN

Journal Article · Wed Jun 01 04:00:00 EDT 1960 · Journal of Immunology (U.S.)

OSTI ID:4020412

Hook, W A; Carey, W F; Muschel, L H

Inoculation of mice with Zymosan or endotoxin caused an initial decline and subsequent rise in lysozyme titers that was similar but not identical with changes in properdin titer. Mice responded to irradiation with progressively decreasing lysozyme levels whereas properdin titers rose to above normal shortly after irradiation and then fell to normal or below normal levels. The serum lysozyme titer in mice thus appeared to he a more consistent indicator of irradiation damage than the properdin titer. Lysozyme could not be substituted for properdin in vitro for the lysis of paroxysmal nocturnal hemoglobinuria erythrocytes, tanric acid treated-erythrocytes, toxoplasmacidal activity, or for the inactivation of C'3. A lysozyme depleted seruna (RL) containing complement and properdin possessed full activity in these systems. (auth)

• Research Organization: Walter Reed Army Inst. of Research, Washington, D.C.
• NSA Number: NSA-15-016843
• OSTI ID: 4020412
• Journal Information: Journal of Immunology (U.S.), Journal Name: Journal of Immunology (U.S.) Vol. Vol: 84; ISSN JOIMA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANTIGENS
BIOLOGY AND MEDICINE
BLOOD SERUM
CARBOHYDRATES
ENDOTOXINS
ENZYMES
ERYTHROCYTES
GLOBULINS
HEMOGLOBIN
IMMUNITY
LYSOZYME
MICE
PROPERDIN
PROTEINS
RADIATION EFFECTS
URINE
X RADIATION
ZYMOSAN