Changes in Serum Properdin of Mice During Tumor Growth and Following Immunization to Ehrlich Ascites Carcinoma.

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Experimental Biology and Medicine

DOI:https://doi.org/10.3181/00379727-109-27101· OSTI ID:4811978

Troeh, M. R.; Slater, C. R.; Larson, W. M.; McKee, R. W.

Employing a modified McNall procedure for determining serum properdin it was shown that in C57/BL mice growing Ehrlich ascites carcinoma there was a progressive drop of serum properdin after 3 days. Similar decreases of serum properdin values in C3H and A/He mice occurred when they were growing Gardner lymphosarcoma and L No. 2 lymphoma, respectively. On the contrary, when C57/ BL mice were given either repeated injections of 2000 r x-irradiated Ehrlich carcinoma, or repeated injections of x-irradiated tumor and 3 to 5 challenges of viable tumor, there was a transient drop with a return to a normal blood level of properdin. However, numerous challenges of mice that received repeated injections of x-irradiated tumor resuited in a significant lowering of the serum properdin, but not to levels produced with actively growing tumor. There appeared to be a correlatton of serum properdin with cancer growth. During cancer growth there was a fall in serum properdin, while regression was accompanied by a rise back to control levels of serum properdin.

• Research Organization: Univ. of California, Los Angeles
• Sponsoring Organization: USDOE
• NSA Number: NSA-16-009774
• OSTI ID: 4811978
• Journal Information: Experimental Biology and Medicine, Journal Name: Experimental Biology and Medicine Journal Issue: 1 Vol. 109; ISSN 1535-3702
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BLOOD SERUM
CANCER
CARCINOGENESIS
IMMUNITY
MICE
PROPERDIN
RADIATION DOSES
TUMORS
X RADIATION