THE RELATIONSHIP OF THE METABOLIC STATE OF DEOXYRIBONUCLEIC ACID DURING X- IRRADIATION TO HeLa S3 GIANT CELL FORMATION

Journal Article · Mon May 01 04:00:00 EDT 1961 · Radiation Research

DOI:https://doi.org/10.2307/3570905· OSTI ID:4018657

Painter, R B; McAlpine, V W.R.; Germanis, M

The probability of giant cell formation as a function of the position of the cell in the DNA metabolic cycle at time of x-irradiation was examined by autoradiographically determining the retention of labeled cells in irradiated populations. It was found that the frequency of labeled giant cells in the population at times of 1 to 5 weeks after irradiation is practically the same as at time zero, regardless of whether the great majority of the labeled cells are in DNA synthesis at the time of irradiation or in the phases before or after DNA synthesis. A tendency, in some experiments, for cells in synthesis at the time of irradiation to be slightly more capable of forming giant cells may indicate that these cells are somewhat less likely to undergo the abortive mitotic action which leads to lytic death in these cultures. (auth)

• Research Organization: Battelle Memorial Inst., Columbus, Ohio
• NSA Number: NSA-15-017950
• OSTI ID: 4018657
• Journal Information: Radiation Research, Journal Name: Radiation Research Vol. Vol: 14
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
CYTOLOGY
METABOLISM
NUCLEIC ACIDS
RADIOAUTOGRAPHY
TRACER TECHNIQUES
X RADIATION