THE EFFECT OF WHOLE-BODY X-IRRADIATION ON THE PASSAGE AND ABSORPTION OF STRONTIUM AND CALCIUM IN THE GASTROINTESTINAL TRACT OF THE RAT
Young male albino rats (100 to 120 gm) were exposed to 285-kvp x rays for 10 minutes at a dose rate of 40 r/min. At various times after irradiation, they were given a dose of Sr/sup 8//sup 5/ and Ca/sup 4//sup 5/ into ligated segments of the small intestine to ascertain the effect of irradiation on absorption. At 2 hours sfter irradiation, the only change noted was a possible depression of absorption in the duodenum. At 16 hours no effect was noted. At 24 hours, an increased permeability of the ileum and jejunum to both Ca/sup 4// sup 5/ and Sr/sup 8//sup 5/ was seen. The effect was present in the ileum at 48 hours for both Ca/sup 4//sup 5/ and Sr/sup 8//sup 5/ but only for Ca/sup 4//sup 5/ in the jejunum. Evidence was obtained that at 2 hours after irradiation the movement of the test solution out of the stomach and along the small intestine was at a slower rate than for the controls. This appeared to explain the increased absorp-tion of Sr/sup 8//sup 5/ seen at a similar time period with intact rats. At 48 hours after irradiation, the movement of the test dose from the stomachs of the irradiated rats was faster than for the control rats. However, a slower movement through the small intestine was detected. This accentuated the increased permeability seen in the ileum. (auth)
- Research Organization:
- New York State Veterinary College, Cornell Univ., Ithaca
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-017951
- OSTI ID:
- 4018656
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Vol. Vol: 14
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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