DOSE-RATE AND THE INDUCTION OF MUTATION IN DROSOPHILA

Journal Article · Sun Sep 01 04:00:00 EDT 1963 · Intern. J. Radiation Biol.

OSTI ID:4018479

Purdom, C E; McSheehy, T W

Drosophila male germ cells were exposed to 800 rad of /sup 60/Co gamma rays at three different dose rates, 0.05, 0.5, and 5.0 rad/min F/sub 0/ males were mated in seven successive broods of which broods I and VII were sampled for IInd chromosome recessive lethal mutations. Mutation frequency was independent of dose rate in each brood. It was concluded that dose-rate had no discernible effect on induced mutatlon frequency in spermatids brood I) or spermatogonia (brood VII). Results are discussed in relation to the hypothesis that the dose- rate effect discovered by Russel in the mouse arose through repair of genetic radiation damage. It is suggested that killing of cells by radiation, which is much more extensive in the mouse than in Drosophila, would be a more plausible mechanism to explain the dose-rate effect than repair, for which there is no corroborative evidence. (auth)

• Research Organization: Medical Research Council, Harwell, Berks, Eng.
• NSA Number: NSA-18-019646
• OSTI ID: 4018479
• Journal Information: Intern. J. Radiation Biol., Journal Name: Intern. J. Radiation Biol. Vol. Vol: 7
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
CHROMOSOMES
COBALT 60
DROSOPHILA
GAMMA RADIATION
GENETICS
GONADS
INSECTS
MUTATIONS
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
RADIOSENSITIVITY
REPRODUCTION
VARIATIONS