EFFECT OF WHOLE-BODY X-IRRADIATION ON PALMITATE-1-C$sup 14$ METABOLISM IN THE RABBIT
The metabolism of albumin-complexed /sup 14/C-labeled palmitic acid was studied in x-irradiated rabbits to denote alterations in triglyceride formation. Rabbits exposed to 1000 r of whole-body x irradiation manifested a normal intravascular removal rate of labeled free fatty acid and an unaltered plasma FFA concentration during the hyperlipemic state. The conversion of albumin-complexed /sup 14/C-labeled palmitic acid to plasma triglyceride was increased fourfold in the x-irradiated group, however. Liver triglyceride concentration in the x- irradiated animals was lower, but specific activities were comparable in sham- and x-irradiated groups. Data from the present study and previous investigations concerning the etiology of radiation lipemia are highiy suggestive that a major factor in the genesis of radiation lipemia in the rabbit is an enhanced rate of formation of plasma triglyceride. (auth)
- Research Organization:
- Univ. of Tennessee, Memphis
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-18-019665
- OSTI ID:
- 4018095
- Journal Information:
- Radiation Res., Journal Name: Radiation Res. Vol. Vol: 21
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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