NUCLEOSIDE PHOSPHATE CONTENTS IN DIFFERENT ORGANS OF RATS AFTER WHOLE-BODY IRRADIATION

Journal Article · Wed Jan 01 04:00:00 EST 1964 · Strahlentherapie (West Germany)

OSTI ID:4017725

Maass, H; Timm, M

Mono-, di- and triphosphonucleosides were determined in blood, liver, spleen, and thymus of rats after total-body irradiation with 3000, 8000, and 20,000 r. Compared to a total-body irradiation with 800 r an increase in the radiation dose caused only a partial amplification of the radioinduced changes of the nucleosidephosphate contents. An increased radiation effect was noted only in the spleen and was determined at certain intervals after irradiation. There was no significant amplification of the changes in the thymus found after 800 r. It is assumed, therefore, that a threshold dose (800 r or below) is sufficient to cause these changes. The displacement of the nucleosidephos phates found in liver after using sublethal doses could obviously not be determined after total- body irradiation with higher doses. Possible causes of the radioinduced changes of the nucleotide metabolism are discussed. (auth)

• Research Organization: Universitat, Hamburg
• NSA Number: NSA-18-019702
• OSTI ID: 4017725
• Journal Information: Strahlentherapie (West Germany), Journal Name: Strahlentherapie (West Germany) Vol. Vol: 123; ISSN STRAA
• Country of Publication: Country unknown/Code not available
• Language: German

Related Subjects

BIOLOGY AND MEDICINE
BLOOD
BODY
IRRADIATION
LETHAL DOSE
LIVER
METABOLISM
NUCLEIC ACIDS
NUCLEOSIDES
ORGANIC PHOSPHORUS COMPOUNDS
PHOSPHATES
QUANTITATIVE ANALYSIS
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RATS
SPLEEN
STANDARDS
THYMUS
VARIATIONS