SOME REMARKS ON THE PHARMACOLOGY OF RADIOPROTECTANT AGENTS
Journal Article
·
· Annals of the New York Academy of Sciences (U.S.)
A striking parallelisra between pharraacological activity and radiation protection was clearly demonstrated for serotonin, epinephrine, histamine, p- aminopropiophenone, and cyanide. This correlation permits the assignment of hypoxia as the probable mechanism whereby these agents protect against the effects of radiation. On the other hand, AET, although very active pharmacologically, probably exerts its radioprotective activity by means other than the production of hypoxia. The greatest liraitation to the use of existing radioprotectants in man and higher animals is their toxicity. It is suggested that methods for attenuating the toxicity of the present effective corapounds must be sought and new nontoxic agents must be devised utilizing established principles of radiation protection. (auth)
- Research Organization:
- Univ. of Rochester, N.Y.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-18-019771
- OSTI ID:
- 4016710
- Journal Information:
- Annals of the New York Academy of Sciences (U.S.), Journal Name: Annals of the New York Academy of Sciences (U.S.) Vol. Vol: 114; ISSN ANYAA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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