TUMORIGENESIS IN TRANSPLANTED IRRADIATED AND NONIRRADIATED OVARIES

Journal Article · Sat Apr 01 04:00:00 EST 1961 · Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst.

OSTI ID:4013227

Gardner, W U

Over 300 hybrid mice were used to determine the incidences of ovarian tumors after irradiation and transplantation of ovaries. Female mice were given 87 or 175 r total-body radiation. Ovaries of these and non-irradiated donors were permitted to remain in place or transplanted subcutaneously or intratesticularly in male hosts. Some irradiated female mice received subcutsneous transplants of nonirradiated ovaries or of testes. Most of the intact and unilaterally castrated males had ovarian grandlosa-cell tumors 600 to 700 days after a non-irradiated ovary was placed in the testis. Only about a third of the irradiated ovaries similarly grafted became turaorous. Nonirradiated ovaries grafted subcutaneously became tumorous in all the castrated male hosts, and two thirds of the irradiated ovaries became tumorous when transplanted in castrated male hosts. Approximately two thirds of the intact irradiated females and one taird of the unilaterally ovariectomized, irradiated mice had ovarian tumors at death. Only 8 percent of the irradlated females that had an ovary transplanted subeutaneously from a young donor had ovarian tumors at death. Grafts of testis did not inhibit ovarian tumorigenesis. The environment provided by the male favored either ovarian tumorigenesis in grafted ovaries from both nonirradiated and irradlated donors or the growth of cells that had become tumorous. The incidence of lymphomas was higher in the male mice bearing grafts of irradiated ovaries. Two male mice bearing granulosacell tumors of the follicular type had mammary adenocarcinomas at death. (auth)

• Research Organization: Yale Univ. School of Medicine, New Haven
• NSA Number: NSA-15-017943
• OSTI ID: 4013227
• Journal Information: Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst., Journal Name: Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst. Vol. Vol: 26; ISSN JNCIA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BODY
CARCINOGENESIS
GONADS
HORMONES
IRRADIATION
MICE
RADIATION EFFECTS
TRANSPLANTS
TUMORS
WHOLE-BODY IRRADIATION