STUDIES ON THE RADIOSENSITIVITY OF FOUR INBRED STRAINS OF MICE

Journal Article · Fri Jan 01 04:00:00 EST 1960 · Nippon Igaku Hoshasen Gakkai Zasshi (Japan)

OSTI ID:4010679

Onoue, M

The influence of strain, body weight, sex, and age on lethal effects of single whole-body x irradiation was studied in 4 inbred strains of mice maintained in the National Institute of Genetics. Strains used were C57BL/6, A/ He, C3H, and C58. All animals at the age of 80 days were exposed to x rays of 560 r,600 r,640 r, or 68O r (160 kvp, HVL 0.96 mm Cu, dose rate 71 r/min), respectively. The LD/sub 50///sub 30/ values obtained in each strain were as follows: C57BL/ 6 584 r, A/He 623 r, C3H 626 r, and C58 634 r. C57BL/6 was the most radiosensitive in terms of the LD/sub 50/ among these strains. Results of irradiation of 680 r (LD/sub 100/ were as follows: the mean survival days of C3H strains were found to be statistically significantly different from the other strains. In the case of C57BL/6 strains, the death following irradiation was distributed over a longer period than in others, and the frequency distribution curve showed two peaks while the other strains had only one. The percentages of body weight loss were different in each strain, according to their differences of radiosensitivity, but were in linear relation with the dose in each case. From the standpoint of the body weight, the heavier mice seemed to be more resistant than the smaller ones when the results were pooled for all strains. No significant sex differences were indicated in the lethal effects of acute x irradiation. According to the results in two strains of A/He and C3H with doses of 600 r or 680 r, the radiosensitivities were high in younger mice and progressively decreased from 20 to 120 days of age. (Abstr. Japan Med., 1: No. 9, 1961)

• Research Organization: Kyoto Univ.
• NSA Number: NSA-15-025892
• OSTI ID: 4010679
• Journal Information: Nippon Igaku Hoshasen Gakkai Zasshi (Japan), Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi (Japan) Vol. Vol: 19; ISSN NHGZA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
BIOLOGY AND MEDICINE
BODY
GENETICS
LETHAL DOSE
LIFETIME
MICE
RADIATION DOSES
RADIOSENSITIVITY
SEX
STATISTICS
WEIGHT
X RADIATION