Relationship of strain, sex, and body weight to survival following sublethal whole-body x-irradiation. [Mice]

Journal Article · Sat May 01 04:00:00 EDT 1976 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574403· OSTI ID:7187429

Holland, J M; Mitchell, T J

Life-shortening effects of whole-body x-irradiation of C3H, BALB/c, RFM, C57BL/6, C3CF/sub 1/, B6RFMF/sub 1/, and a four-way cross were compared. Male and female mice exposed to 300 R at 5-6 weeks of age showed significant life shortening in all strains and crosses. Females were, in general, 1.5 times more sensitive than males of the same strain, suggesting a constant effect of sex. There were substantial differences in sensitivity within the same sex among strains and it was found that this strain-specific difference was highly correlated with body weight at 6 weeks of age. On this basis a hypothesis has been advanced which views some of the strain-specific differences in radiation sensitivity as due to differences in maturational rate or to processes which are highly correlated with maturational rate.

• Research Organization: Oak Ridge National Lab., TN
• OSTI ID: 7187429
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 66:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL VARIABILITY
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICE
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
SEX
SURVIVAL TIME
VERTEBRATES
WEIGHT
WHOLE-BODY IRRADIATION
X RADIATION