CONTRIBUTION TO THE KNOWLEDGE OF THE RADIOTOXICOLOGICAL PROPERTIES OF CERIUM-144 (in French)
The metabolism of carrier-free Ce/sup 144/ in the colloidal and ionic states was studied. The kinetics of the radioisotope in the blood, after intravenous injection, is a function of the physico-chemical state in the injected solution. The initial distribution and the method of transfer in the blood are also functions of the physico-chemical state. In the case of ionic cerium, elimination from the liver is very rapid. Fixation by the skeleton is slower and attains a maximum toward the thirtieth day. Cerium is excreted in the feces. A preliminary study of the radiotoxicity of Ce/sup 144/ in the rabbit shows that 0.66 mu c of Ce/sup 144/-Pr/sup 144/ per gr am of body weight causes the death of 8 out of 10 rabbits in sixteen days. The sensitivity of the rabbit appears to be greater than that of the rat after internal radiocontamination, but less after external contamination. Some hematological modifications, after internal contamination, are not superposable on those occurring after external exposure. The cumulative beta doses at the liver level after injection of 0.66 nu c/g body weight are of the order of 1500 rads on the sixteenth day. (J.S.R.)
- Research Organization:
- Comissariat a l'Energie Atomique, Paris
- NSA Number:
- NSA-15-019123
- OSTI ID:
- 4004015
- Journal Information:
- Bull. inform. sci. et tech. (Paris), Journal Name: Bull. inform. sci. et tech. (Paris) Vol. Vol: No. 47
- Country of Publication:
- Country unknown/Code not available
- Language:
- French
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